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Celebrex - FDA prescribing information, side effects and uses
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Fever (9%) Dyspepsia (8.8%) Upper respiratory tract infection (8.1%) Arthralgia (7%) Cough (7%) Vomiting (6%) Diarrhea (5.6%) Gastroesophageal reflux (5%) Sinusitis (5%) Abdominal pain (4.1%) Nausea (3.5%) Back pain (2.8%) Insomnia (2.3%) Pharyngitis (2.3%) Flatulence (2.2%) Rash (2.2%) Dizziness (2%) Peripheral edema (2%) Congestive heart failure, hypertension Increased risk of adverse cardiovascular events and skin reactions Caution in asthma (bronchial), bleeding disorder, bronchospasm, duodenal/gastric/peptic ulcer, renal impairment Risk of GI bleeding, ulceration, and perforation Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include elderly individuals; those with impaired renal function, hypovolemia, heart failure, liver dysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers Anemia may occur; monitor hemoglobin or hematorcrit in long term treatment patients Heart Failure(HF) risk Pregnancy category: C; D at ≥30 weeks' gestation (may cause premature closure of ductus arteriosus) Quebec Pregnancy Registry identified 4705 women who had spontaneous abortions by 20 weeks' gestation; each case was matched to 10 control subjects (n=47,050) who had not had spontaneous abortions; exposure to nonaspirin NSAIDs during pregnancy was documented in ~7.5% of cases of spontaneous abortions and in ~2.6% of controls Lactation: Drug enters breast milk; use caution The above information is provided for general informational and educational purposes only.
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